Polygenic Risk Score

**Background:** Polygenic risk score (PRS) analyses have become an integral part of biomedical research, exploited to gain insights into shared aetiology among traits, to control for genomic profile in experimental studies, and to strengthen causal …

In case control studies, samples are usually ascertained in a non-random way, where the sample prevalence might not represent the population prevalence of the trait, leading to biased estimate of the coefficient of determination (R2). Previous …