Trans-ancestry polygenic risk score method improving portability across populations.
Gene-set-based polygenic score method for pathway-level genetic signal.
Corrects inflation in polygenic score analyses caused by sample overlap.
Standalone polygenic risk score software for biobank-scale data. 1,900+ citations.
**Background:** Polygenic risk score (PRS) analyses have become an integral part of biomedical research, exploited to gain insights into shared aetiology among traits, to control for genomic profile in experimental studies, and to strengthen causal …
In case control studies, samples are usually ascertained in a non-random way, where the sample prevalence might not represent the population prevalence of the trait, leading to biased estimate of the coefficient of determination (R2). Previous …